One of the key challenges in cancer research is finding ways to selectively eliminate cancer cells without harming healthy tissues. This makes understanding cell death mechanisms in cancer cells critical for developing effective treatments. Ferroptosis, a recently recognized form of programmed cell death driven by iron, has emerged as a promising approach for targeting cancer cells, which have higher iron requirements than normal cells. Inducing ferroptosis has been shown to overcome resistance to various chemotherapeutic agents and targeted therapies, enhancing their effectiveness and decreasing cancer resistance. To explore the protective effects of quercetin, a flavonoid metabolite, and the cell death pathways it engages, experiments were conducted using HT-29 and HCT-116 colon cancer cell lines treated with quercetin and an anticancer drug. Cell viability was measured after 24 and 48 hours of incubation with varying logarithmic concentrations of quercetin and doxorubicin, both independently and in combination. The study focused on identifying the cell death pathways activated by these treatments by analyzing apoptosis markers APAF-1 and CASP-3, along with ferroptosis markers GPx4 and ACSL-4. The results indicated that quercetin alone elevated APAF-1 and CASP-3 levels in both colon cancer cell lines, thus promoting the apoptotic pathway. In terms of ferroptosis, the combination treatment increased ACSL-4 expression while reducing GPx4, indicating the induction of ferroptosis and a synergistic effect on cancer cells. These findings point to the potential for further investigation into combining ferroptosis-inducing agents and the signaling pathways that trigger different forms of cell death.
This study presents the Knowledge-Aware Model (KAM), a pioneering approach in sports analytics for predicting highlights in badminton matches. Utilizing extensive rally-by-rally data from significant tournaments, the model integrates domain-specific insights with data-driven techniques. Our analysis of over 5,180 rallies from 140 singles matches reveals the model`s effectiveness, outperforming baseline and state-of-the-art methods with an F1-score of 0.793. KAM`s innovative use of match statistics and rally-specific data opens new horizons in sports analytics, potentially applicable beyond badminton to multimedia analysis and recommendation systems, demonstrating a significant advancement in AI-driven sports analytics.
In order to improve its robustness, a Variable Structure Control (VSC) is applied to a vector-controlled Induction Machine (IM) system drive, the robustness is ameliorated and compared using several intelligent methods of observation, Sliding Mode Control (SMC) with an Extended Luenberger Observer (ELO) and Extended Kalman Filter (EKF) Observer, controlled by Proportional Integral (PI) and Fuzzy-PI (FPI) controllers. The results show the effectiveness of the proposed approach.
Background: Dental caries reaches 60-90% children within 8-10 years old and most of adults, that is able to give any obstacles of the quality of life. Purpose: This study aimed to recognize the relation between dental caries and the quality of life in Banyuputih Villlage, Wringin District, Bondowoso. Method: The type of this study was observational with cross sectional approach. The subjects were children within 8-10 years old in Banyuputih Villlage, Wringin District, Bondowoso. Sampling technique was purposive (92 sample). The variables were dental caries and the quality of life. The measurement for dental caries used index def-t, while the quality of life by using Child Perception Questionnaire 8-20 (CPQ 8-10). The data analyzed by using Spearman Correlation Test. Result: The result showed that the mean of dental caries was 6.01 and the mean of the quality of life was 80,79. There was correlation between dental caries and the quality of life (p=0.002) with the negative correlation effect. Conclusion: There was a correlation between dental caries and the quality of life.
Dolomite enriched with nitrogen, phosphorus and potassium (trade name Fertdolomite: 24.0% CaO + 16.0% MgO + 3.0% N + 2.5% P2O5 + 3.0% K2O) was applied in autumn of 2011 in three rates (3.56, 7.14 and 14.25 t ha-1) with aim of testing impact on maize and winter wheat status in crop rotation on Gorjani acid soil (pH in 1nKCl = 4.13; hydrolitical acidity 6.78 cmol kg-1) of Osijek-Baranya County. \nIn 2012 the maize yield was pretty low (2.71 t ha-1), which was mainly caused by high contribution of barren plants due to drought high air-temperature stress in maize flowering. The average maize grain yield under normal weather conditions of 2014 was 12.15 t/ha and by Fertdolomite yield was significantly increased by 11%. \nIn the 2012/2013 growing season as affected by Fertdolomite wheat yield was increased by 22% (6.93 and 8.47 t ha-1, respectively) and in 2015 by 25% (6.46 and 8.08 t ha-1, respectively). By the highest Fertdolomite rate were significantly increased grain quality parameters of wheat (2-year averages: comparison with the control), for example protein (10.8% and 11.9%, respectively), wet gluten (27.1% and 30.1%, respectively) and sedimentation (32.3 ml and 38.2 ml), while differences in other parameters (thousand grain weight, hectoliter mass and starch contents) were within statistical error (Table 4). However, these quality parameters were under considerable influences of growing season specifies (2013 and 2015, respectively) as follows: 10.8% and 11.9% (protein contents), 26.9% and 30.9% (wet gluten), 31.0 ml and 39.6 ml (sedimentation).
Adverse effects are important factors that threaten the survival and quality of life of humans; it can impose great cost to the health system of a country. Co-trimoxazole is an antibiotic which is achieved by the combination of sulfamethoxazole and trimethoprim. The drug, like other types of antibiotics has many side effects on different body systems. This report is about 30 year old woman, who referred to the emergency department followed by numbness of the tongue after taking co-trimoxazole. The patient didn\'t take other medications during the past month and this drug has been prescribed for colds and clinical symptoms have shown after taking 8 of the drug. The patient had other complications that after receiving oxygen and outpatient treatment, all symptoms resolved, except for numbness of the tongue. After 10 days, the problem was solved. It is necessary that respected doctors should also consider the complication related to the numbness of the tongue when prescribing co-trimoxazole, which is also widely used drug.
In this paper we developed a module helps NC programming instructions machining standard in CAM environment. This module allows learning to numerically as well as conversational programming mode. Two parties have been developed. The first deals with the problem of incompatibility of functions preparatory commands FANUC, FAGOR, NUM, SINUMERIK in the Turning and milling. In the second part, it was developed a module contributing to the adaptation of standard machining instructions in CAM environment.
A 23-year-old female presented with left gluteal pain and limping for one year after motorcycle accident. Examination showed tip-toeing antalgic gait, left lower limb was internally rotated with 2.8 cm shortening without neurovascular impairment. Radiograph revealed posterior dislocation with fracture of the roof and posterior column of the acetabulum. Hence gradual traction was commenced up to 14.6 kg within a month. Open reduction was done but abduction cast was applied to keep the left hip externally rotated and abducted. \nOn follow up she was able to ambulate after 2 months. MRI after 4 months suggested sign of osteonecrosis of the superior head and 8 months later she been complaining of anterior hip and knee pain on full weight bear without instability. She had started working but requires occasional analgesia. The chronological and related future problems with further treatment options had been well informed to patient.
This paper presents an investigation of the surface roughness in a turning process of SAE 1020 and SAE 1045 materials in order to suggest experimental models. The main objectives are to predict the surface roughness, to select the optimal cutting parameters, and to analyze the effects of cutting parameters. The study of this work allows to find more efficient methods to assist the Computer Numeric Control (CNC) turning process, optimizing its cutting parameters: cutting speed, feed rate and depth of cut. Factorial design was used for the experiment plan. At work, we investigated the turning conditions for SAE 1020 and 1045 steels with carbide tool. The measured data were analyzed by regression analysis. From the experimental results and regression analysis, this research project suggested the experimental equations, proposed the optimal cutting parameters, and analyzed the effects of cutting parameters on surface roughness.